I'm still getting used to the new site design, but I immediately notice one tangible difference that I don't care for: When browsing questions in the expanded questions view, it is no longer possible to tell if the question has an accepted answer. It does still render differently on the main title-only view, but that difference seems arbitrary and I suspect it's a bug. I, personally, always browse the /questions view because it's far more usable to me.
Currently, the rendering of "one or more answers" and "an answer has been accepted" is identical in the main questions-only view. I think it used to be that black text showed 0 answers, green text showed 1-or-more answers, and a green background that looked like a green outline of a "covered platter," which I always thought was clever. Compare, for example, accepted answer rendering at the "default" design at Coffee.SE main page versus the expanded page -- both Coffee.SE views render "accepted answer questions" consistently.
I am not sure if this is intentional, or if this is The New Way for the SE network as a whole, but regardless of rendering I prefer the "distinguishability" of questions with an accepted answer.